Nancy
Poster Presentations at the AACR 2024 Annual Meeting for OBI-992 and GlycOBI™ ADC platform
Title: OBI-992, a novel TROP2 targeting antibody-drug conjugate, displayed excellent antitumor efficacy in various animal models Abstract presentation number: 1893 / Poster number 23/4 PDF LINK Title: In vitro …
Investigation of the impact of Globo-H expression on the progression of gastric cancer
Globo-H (GH), a globo-series glycosphingolipid antigen that is synthesized by key enzymes β1,3-galactosyltransferase V (β3GalT5), fucosyltransferase (FUT) 1 and 2, is highly expressed on a variety of epithelial cancers rendering …
Phase 1 dose-escalation study evaluating the safety, pharmacokinetics, and clinical activity of OBI-3424 in patients with advanced or metastatic solid tumors
Background: Report of a Phase 1 dose-escalation study of OBI-3424 monotherapy in patients with advanced solid tumors (NCT03592264). Methods: A classic 3 + 3 design was used to determine the …
Immunogenicity of a spike protein subunit-based COVID-19 vaccine with broad protection against various SARS-CoV-2 variants in animal studies
SARS-CoV-2 pandemic has profound impacts on human life and global economy since the outbreak in 2019. With the new variants continue to emerge with greater immune escaping capability, the protectivity …
First-in-Human Study of OBI-999, a Globo H-Targeting Antibody-Drug Conjugate, in Patients With Advanced Solid Tumors
Purpose: OBI-999 is a novel antibody-drug conjugate comprising the Globo H-targeting antibody (OBI-888) linked to the cytotoxic payload monomethyl auristatin E. OBI-999 demonstrated excellent dose-dependent tumor growth inhibition in breast, …
The clinical relevance of humoral immune responses to Globo H-KLH vaccine adagloxad simolenin (OBI-822)/OBI-821 and expression of Globo H in metastatic breast cancer
An international randomized phase II trial of Globo H (GH) vaccine, adagloxad simolenin/OBI-821 in 349 patients with metastatic breast cancer showed longer progression-free survival (PFS) in vaccinated patients who developed …
Poster Presentations at AACR 2022 Annual Meeting for OBI-3424 and Globo H Science
Title: OBI-3424, an AKR1C3-activated prodrug, exhibits in vivo synergistic anti-tumor effect in combination with pembrolizumab by induction of immunogenic cell death Poster number: 6111 / Abstract number: 2922 Title: High …
The role of Globo H and SSEA-4 in the development and progression of cancer, and their potential as therapeutic targets
Glycans, chains of sugar molecules found conjugated to cell proteins and lipids, contribute to their growth, movement and differentiation. Aberrant glycosylation is a hallmark of several medical conditions including tumorigenesis. …
The Company’s Board of Directors resolved to issue employee stock options and the subscription rules
1. Date of the Board of Directors resolution: 2021/08/06 2. Issue period: Pursuant to the “Regulations Governing the Offering and Issuance of Securities by Securities Issuers,” issued within one year …
New appointment of Audit Committee member
1. Date of occurrence of the change: August 6, 2021 2. Name of the functional committees: Audit Committee 3. Name and resume of the previous position holder: None 4. Name …