OBI-833 (Vaccine)

OBI-833 (Vaccine)

Active Immuno-Oncology Therapy

OBI-833 is another Globo H-based active immunotherapy. Its safety has been assessed in a Phase I dose escalation and cohort expansion study. OBI-833 demonstrated a favorable safety profile and generated detectable anti-Globo H IgM/IgG responses. In addition, OBI-833 rendered some non-small cell lung cancer patients who were treated with an EGFR TKI durable stable disease status.

A Phase II study is currently enrolling. The EGFR TKI that is combined with OBI-833 in this study has recently been changed from erlotinib to afatinib to align with the current clinical practice and enhance enrollment​.