1. Date of occurrence of the change: August 6, 2021
2. Name of the functional committees: Audit Committee
3. Name and resume of the previous position holder: None
4. Name and resume of the new position holder:
Howard S. Lee/ Chairman of Taho Pharmaceuticals Ltd.

Chairman of Transwell Biotech Co., Ltd.
Independent Director of Sunko Ink Co., Ltd.
Independent Director of Genovate Biotechnology Co., Ltd.
Independent Director of Taimed Biologics Inc.
Director of Easywell Biomedicals, Inc.
Director of Industrial Technology Investment Corporation
Director of Amphastar Pharmaceuticals, Inc.
Director of Capso Vision Inc.
Director of Taiwan Bio Industry Organization
Director of Taiwan Society for the Chest Care

5. Circumstances of change (Please enter “resignation”, “dismissal”, “term expired”, “death” or “new appointment”): New appointment
6. Reason of the change: New appointment on Board of Director meeting on August 6, 2021.
7. Original term (from __ to __): From June 27, 2019 to June 26, 2022
8. Effective date of new appointment: August 6, 2021
9. Any other matters that need to be specified: None