AKR1C3

AKR1C3

AKR1C3 Aldo Keto Reductase Family 1 Member C3

AKR1C3 belongs to the superfamily of NAD(P)H-dependent reductases. AKR1C3 can convert aldehyde and ketone to the corresponding primary and secondary alcohols. AKR1C3 plays an important role in the carbonyl metabolism in wide range of endogenous and exogenous substances as well as xenobiotics and chemical carcinogens.

It is reported that AKR1C3 over-expressed in more than 15 solid and liquid tumors, especially for drug-resistance and hard-to-treat tumors, such as hepatocellular carcinoma (HCC), castration-resistant prostate cancer (CRPC) and T-cell acute lymphoblastic leukemia (T-ALL).

In addition, the expression level of AKR1C3 in different cancer types can be evaluated on sliced tumor tissues or circulating tumor cells by Immunohistochemistry (IHC) to select cancer patients with high level of AKR1C3 expression, who are most likely to be benefited from OBI-3424 treatment. The correlation between the expression level and treatment outcomes will provide the guideline to establish effective strategy for clinical precision therapy.