1.Date of the board of directors resolution or date of occurrence of the change:2023/12/29
2.Position (Please enter chairperson or president/general manager): Chairperson
3.Name of the previous position holder: Yun Yen
4.Resume of the previous position holder: Chairperson of the Board, OBI Pharma Inc.
5.Name of the new position holder: Kung-Yee Liang, the representative of institutional director, Sheng Cheng Investment Co., Ltd.
6.Resume of the new position holder: Former president of National Yang-Ming University/ Former president of National Health Research Institutes/
Distinguished Chair Professor at Feng Chia University
7.Circumstances of change (Please enter ”resignation”, ”dismissal”, ”term expired” , ”job relocation”, ”severance”, ”retirement”,
”death” or ”new appointment”):New appointment
8.Reason for the change: New appointment
9.Effective date of the new appointment: 2023/12/29
10.Any other matters that need to be specified(the information disclosure also meets the requirements of Article 7, subparagraph 6
of the Securities and Exchange Act Enforcement Rules, which brings forth a significant impact on shareholders rights or the price of
the securities on public companies.): None