1.Date of occurrence of the change: 2022/10/6
2.Elected or changed position (Please enter institutional director, institutional supervisor, independent director, natural-person director or natural-person supervisor): institutional director
3.Title and name of the previous position holder: AbProtix Inc.
4.Resume of the previous position holder: Institutional director of AP Biosciences
5.Title and name of the new position holder: Not applicable
6.Resume of the new position holder: Not applicable
7.Circumstances of change (Please enter “resignation”, “dismissal”, “term expired”, “death” or “new appointment”): resignation
8.Reason for the change: resignation of Institutional director
9.Number of shares held by the new position holder when elected: Not applicable
10.Original term (from __________ to __________): 2021/6/4~2024/6/3
11.Effective date of the new appointment: Not applicable
12.Turnover rate of directors of the same term: 1/5
13.Turnover rate of independent directors of the same term: Not applicable
14.Turnover rate of supervisors of the same term: Not applicable
15.Change in one-third or more of directors (Please enter “Yes” or “No”): No
16.Any other matters that need to be specified: AP Biosciences received the resignation letter of institutional director, AbProtix Inc., on 2022/10/06. The effective date of resignation was 2022/11/08.