Announcement of the resignation of natural-person director

1.Date of occurrence of the change:2023/12/20
2.Elected or changed position (Please enter institutional director, institutional supervisor, independent director,
natural-person director or natural-person supervisor): natural-person director
3.Title and name of the previous position holder: Director Yun Yen
4.Resume of the previous position holder: Chairperson of the Board, OBI Pharma Inc.
5.Title and name of the new position holder: Not applicable
6.Resume of the new position holder: Not applicable
7.Circumstances of change (Please enter “resignation”, “dismissal”, “term expired”, “death” or “new appointment”): resignation
8.Reason for the change: resignation
9.Number of shares held by the new position holder when elected: Not applicable
10.Original term (from __________ to __________):2022/6/27~2025/6/26
11.Effective date of the new appointment: Not applicable
12.Turnover rate of directors of the same term:1/7
13.Turnover rate of independent directors of the same term: Not applicable
14.Turnover rate of supervisors of the same term: Not applicable
15.Change in one-third or more of directors (Please enter “Yes” or “No”):No
16.Any other matters that need to be specified(the information disclosure also meets the requirements of Article 7, subparagraph 6
of the Securities and Exchange Act Enforcement Rules, which brings forth a significant impact on shareholders rights or the price of
the securities on public companies.):
The Company received the resignation letter of Dr. Yun Yen on 2023/12/20, to resign his position as Chairperson and director of the Company. The
effective date is set on 2023/12/29.