1.Date of occurrence of the change: 2022/12/29
2.Elected or changed position (Please enter institutional director, institutional supervisor, independent director, natural-person director or natural-person supervisor): natural-person director
3.Title and name of the previous position holder: Director Michael Chang
4.Resume of the previous position holder: Chairman of the Board and CEO, OBI Pharma Inc.
5.Title and name of the new position holder: N/A
6.Resume of the new position holder: N/A
7.Circumstances of change (Please enter “resignation”, “dismissal”, “term expired”, “death” or “new appointment”): death
8.Reason for the change: death
9.Number of shares held by the new position holder when elected: N/A
10.Original term (from __________ to __________): 2022/06/27~2025/06/27
11.Effective date of the new appointment: N/A
12.Turnover rate of directors of the same term: 1/7
13.Turnover rate of independent directors of the same term: N/A
14.Turnover rate of supervisors of the same term: N/A
15.Change in one-third or more of directors (Please enter “Yes” or “No”): No
16.Any other matters that need to be specified: None