Announcement of change of CEO

1.Date of the board of directors resolution or date of occurrence of the change: 2023/06/02
2.Position (Please enter chairperson or president/general manager): CEO
3.Name of the previous position holder: Yun Yen
4.Resume of the previous position holder: Chairman of the Board, OBI Pharma Inc.
5.Name of the new position holder: Heidi Wang
6.Resume of the new position holder: VP, Oncology Head, Global Regulatory Sciences, Bristol Myers Squibb Company
7.Circumstances of change (Please enter ”resignation”, ”dismissal”, ”term expired” , ”job relocation”, ”severance”, ”retirement”, ”death” or ”new appointment”): new appointment
8.Reason for the change: new appointment
9.Effective date of the new appointment: 2023/06/05
10.Any other matters that need to be specified(the information disclosure also meets the requirements of Article 7, subparagraph 6 of the Securities and Exchange Act Enforcement Rules, which brings
forth a significant impact on shareholders rights or the price of the securities on public companies.):
The Board of Directors appoint Heidi Wang as CEO and Spokesperson today.