1.Date of occurrence of the change:2023/06/27
2.Elected or changed position (Please enter institutional director, institutional supervisor, independent director, natural-person director or natural-person supervisor): Natural-person director
3.Title and name of the previous position holder: Not applicable.
4.Resume of the previous position holder: Not applicable.
5.Title and name of the new position holder: Director Yun Yen
6.Resume of the new position holder: Yun Yen/ Chairman of the Board, OBI Pharma Inc.
7.Circumstances of change (Please enter “resignation”, “dismissal”, “term expired”, “death” or “new appointment”): new appointment
8.Reason for the change: new appointment
9.Number of shares held by the new position holder when elected: Director Yun Yen/ 0 shares
10.Original term (from __________ to __________): 2022/06/27 ~ 2025/06/26
11.Effective date of the new appointment: 2023/06/27
12.Turnover rate of directors of the same term: 1/7
13.Turnover rate of independent directors of the same term: Not applicable.
14.Turnover rate of supervisors of the same term: Not applicable.
15.Change in one-third or more of directors (Please enter “Yes” or “No”): No
16.Any other matters that need to be specified(the information disclosure also meets the requirements of Article 7, subparagraph 6 of the Securities and Exchange Act Enforcement Rules, which brings
forth a significant impact on shareholders rights or the price of the securities on public companies.): None